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In contrast, resmetirom targets hepatic THR- directly, improving intrahepatic lipid handling and fibrogenesis, with minor effects on systemic weight [Figure 1C]

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Adverse events included gastrointestinal effects (e.g., nausea, vomiting, abdominal pain), fainting, headache, migraine, dehydration, acute pancreatitis and gallstones

In some cases an MRI or ultrasound may be required to assess the severity of the condition as well as rule out other possible causes of pain3

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